一、个人简历
姓名：孙朝跃
性别：男
籍贯：江苏省泗洪县
出生年月：1989.12
民族：汉族
政治面貌：中共党员
学历：博士
职称：助理研究员
电子邮箱：sunchaoyue@wxc.edu.cn
二、教育学习
2010-09 至 2014-07，山西中医学院, 中药学, 学士
2014-09 至 2016-07, 广州中医药大学, 中药学, 硕士
2016-09 至 2019-07, 广州中医药大学, 中西医结合基础, 博士
2019-07 至 2021-11, 中山大学肿瘤防治中心，博士后
2021-11 至 今, 皖西学院, 生物与制药工程学院, 助理研究员
三、研究方向
中药药理药效与物质基础研究
四、讲授课程
《中药学》、《中药药理学》、《药理学》、《神农本草经导读》。
五、科研情况
主持课题：
1、安徽省高校科研重点项目，基于IL-17/MAPK信号通路探讨多花黄精干预酒精性胃黏膜损伤的作用机制（2023AH052647），10万元。
参与课题：
1、 国家自然基金项目（NO: 81403169）“基于Keap1-Nrf2/NF-κB通路平衡体系研究广藿香活性成分抗急性肺损伤的作用机制”；负责主要研究部分。
2、 广东省自然科学基金（NO: 408140213024）“广藿香活性成分干预Keap1-Nrf2与NF-κB通路平衡体系抑制急性肺损伤的机制研究”，负责主要研究部分。
3、 广东省省级科技计划项目（NO: 2014A020221023）“穿心莲制剂对抗癌药物的增效减毒作用及机制研究”；负责主要研究部分。
4、 加拿大泰瑞•福克斯癌症科研基金（NO:YN2014TF04）罗勒多糖对贝伐单抗联合化疗药物治疗晚期肺腺癌的增效作用研究，2014/10-2017/10，负责体外细胞耐药研究。
5、 国家自然科学基金青年项目（NO:81403142）罗勒多糖调控乏氧微环境下上皮间质转化（EMT）抑制肝癌侵袭转移的机制研究，2015/01-2017/12，负责动物实验。
六、个人成果
论文著作：
1、Sun CY, Xu LQ, Zhang ZB, Chen CH, Huang YZ, Su ZQ, Guo HZ, Chen XY, Zhang X, Liu YH, Chen JN, Lai XP, Li YC, Su ZR. Protective effects of pogostone against LPS-induced acute lung injury in mice via regulation of Keap1-Nrf2/NF-κB signaling pathways. International Immunopharmacology. 2016(32):55-61.
2、Zhang X*, Sun CY*, Zhang YB, Guo HZ, Feng XX, Peng SZ, Yuan J, Zheng RB, Chen WP, Su ZR, Huang XD. Kegan Liyan oral liquid ameliorates lipopolysaccharide-induced acute lung injury through inhibition of TLR4-mediated NF-κB signaling pathway and MMP-9 expression. Journal of Ethnopharmacology. 2016,186:91-102. (并列第一作者)
3、Sun CY, Zhu Y, Li XF, Wang XQ, Tang LP, Su ZQ, Li CY, Zheng GJ, Feng B. Scutellarin increases cisplatin-induced apoptosis and autophagy to overcome cisplatin resistance in non-small cell lung cancer via ERK/p53 and c-met/AKT signaling pathways. Frontiers in Pharmacology. 2018,9, 92.
4、Sun CY, Zhang QY, Zheng GJ, Feng B. Autophagy and its potent modulators from phytochemicals in cancer treatment. Cancer chemotherapy and pharmacology. 2019. 83(1): 17-26.
5、Sun CY, Zhang QY, Zheng GJ, Feng B. Phytochemicals: current novel strategy to reverse cisplatin resistance in cancer treatment. Biomedicine & pharmacotherapy. 2019, 110: 518-527.
6、Sun CY, Nie J, Zheng ZL, Zhao J, Wu LM, Zhu Y, Su ZQ, Zheng GJ, Feng B. Renoprotective effect of scutellarin on cisplatin-induced renal injury in mice: impact on inflammation, apoptosis, and autophagy. Biomed Pharmacother. 2019.112:108647.
7、Sun CY, Nie J, Huang JP, Zheng GJ, Feng B. Targeting STAT3 inhibition to reverse cisplatin resistance. Biomedicine & pharmacotherapy. 2019,117:109135.
8、Chao-Yue Sun, Di Cao, Qian-Nan Ren, Shan-Shan Zhang, Ning-Ning Zhou, Shi-Juan Mai, Bing Feng, Hui-Yun Wang. Combination treatment with inhibitors of ERK and autophagy enhances antitumor activity of Betulinic acid in non-small cell lung cancer in vivo and in vitro. Frontiers in Pharmacology. 2021. 12: 684243. doi: 10.3389/fphar.2021.684243.
9、Chao-Yue Sun, Yi-Zhuo Li, Di Cao, Yu-Feng Zhou, Mei-yin Zhang, Hui-Yun Wang. Rapamycin and trametinib: a rational combination for treatment of NSCLC. International Journal of Biological Sciences. 2021. 17(12):3211-3223.
12、Chao-Yue Sun, Zuo-Liang Zheng, Cun-Wu Chen, Bao-Wei Lu, Dong Liu 1Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions Against High-Fat Diet-Induced Metabolic Diseases.Front Microbiol. 2022,13:859206.
13、Chao-Yue Sun, Na Yang, Zuo-Liang Zheng, Dong Liu, Qi-Lin Xu. T helper 17 (Th17) cell responses to the gut microbiota in human diseases. Biomedicine & pharmacotherapy. 2023,161:114483.
14、Qilin Xu, Jun Chen, Zihao Wang, Yongjun Zang, Guosi Li, Fucheng Zhu, Dong Liu, Chaoyue Sun. Two-step flow synthesis of Olaparib in microreactor: Route design, process development and kinetics research. Chemical Engineering Journal. 2023, 471 (2023) 144304.
15、Guo HZ, Zhang ZB, Su ZQ, Sun CY, Zhang X, Zhao X, Lai X, Su ZR, Li Y, Zhan JY. Enhanced anti-tumor activity and reduced toxicity by combination andrographolide and bleomycin in ascitic tumor-bearing mice. Eur J Pharmacol. 2016 (766): 52-63.
16、Luo DD, Chen XY, Zhang ZB, Sun CY, Zheng YF, Liu YH, Wang XF, Wang Q, Zhan JY, Su ZR. Different effects of (+)-borneol and (-)-borneol on the pharmacokinetics of osthole in rats after oral administration. Molecular Medicine Reports. 2017, 15(6):4239-46.
17、Xu LQ, Xie YL, Gui SH, Zhang X, Mo ZZ, Sun CY, Li CL, Luo DD, Zhang ZB, Su ZR, Xie JH. Polydatin attenuates d-galactose-induced liver and brain damage through its anti-oxidative, anti-inflammatory and anti-apoptotic effects in mice. Food Function. 2016,7(11):4545-4555.
18、Su ZQ, Liu YH, Guo HZ, Sun CY, Xie JH, Li YC, Chen JN, Lai XP, Su ZR, Chen HM. Effect-enhancing and toxicity-reducing activity of usnic acid in ascitic tumor-bearing mice treated with bleomycin. Int Immunopharmacol. 2017,46:146-155.
21、Nie J, Yang HM, Sun CY, Liu YL, Zhuo JY, Zhang ZB, Lai XP, Su ZR, Li YC. Scutellarin enhances antitumor effects and attenuates the toxicity of Bleomycin in H22 ascites tumor-bearing mice. Frontiers in Pharmacology. 2018,14;9:615.
22、Tang LP, He SM, Zhu Y, Feng B, Su ZQ, Liu B, Xu FF, Wang XQ, Liu HY, Li CT, Zhao J, Zheng XR, Li CY, Sun CY, Lu CJ, Zheng GJ. Down-regulated miR-187 contributes to the keratinocytes hyper-proliferation in psoriasis. Journal of Cellular Physiology. 2019,234: 3661-3674.
24、Feng B, Zhu Y, Sun CY, Su Z, Tang L, Li C, Zheng G. Basil polysaccharide inhibits hypoxia-induced hepatocellular carcinoma metastasis and progression through suppression of HIF-1α-mediated epithelial-mesenchymal transition. Int J Biol Macromol. 2019, 137: 32-44.
25、Zhuo, JY , Chen, BY, Sun, CY, Jiang, T, Chen, ZW, Liu, YL, Nie, J , Yang, HM, Zheng, JN, Lai, XP, Su, ZR, Li, CW, Li, YC. Patchouli alcohol protects against chronic unpredictable mild stress-induced depressant-like behavior through inhibiting excessive autophagy via activation of mTOR signaling pathway. BIOMEDICINE & PHARMACOTHERAPY. 2020.7. DOI: 10.1016/j.biopha.2020.11011512.
26、Zuqing Su, Kexue Zeng, Bing Feng, Lipeng Tang, Chaoyue Sun, Xieqi Wang, Caiyun Li, Guangjuan Zheng, Ying Zhu. Kun-Dan decoction ameliorates insulin resistance by activating AMPK/mTOR-mediated autophagy in high-fat diet-fed rats. Frontiers in Pharmacology. 2021. doi.org/10.3389/fphar.2021.670151.
27、Qiannan Ren, Hong Zhang, Chaoyue Sun, Yufeng Zhou, Xuefeng Ynag, Jianwu Long, Xiaoxing Li, Shijuan Mai, Meiyin Zhang, Huizhong, Zhang, Haiqiang Mai, Minshan Chen, Steven X.f. Zheng, Huiyun Wang. Phosphorylation of Androgen Receptor by mTORC1 Promotes Liver Steatosis and Tumorigenesis. Hepatology. 2021. 8. doi:10.1002/hep.32120.
28、Nie J, Liu Y, Sun C, Zheng J, Chen B, Zhuo J, Su Z, Lai X, Chen J, Zheng J, Li Y. Effect of supercritical carbon dioxide fluid extract from Chrysanthemum indicum Linné on bleomycin-induced pulmonary fibrosis. 2021 Sep 25;21(1):240.
29、Binbin Du, Jia Wu, Md Samiul Islam, Chaoyue Sun, Baowei Lu, Peipei Wei, Dong Liu, Cunwu Chen. Genome-wide meta-analysis of QTL for morphological related traits of flag leaf in bread wheat. PLoS One. 2022;17(10):e0276602.